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Title:

nhibiting serine synthesis pathway by PHGDH inhibition reprograms skeletal muscle cell metabolism and impairs anabolic processes

Document type:
Konferenzbeitrag
Contribution type:
Poster
Author(s):
Sakari Mäntyselkä, Kalle Kolari, Philipp Baumert, Laura Ylä-Outinen, Lauri Kuikka, Suvi Lahtonen, Perttu Permi, Henning Wackerhage, Elina Kalenius, Riikka Kivelä, Juha J Hulmi
Abstract:
Introduction: Skeletal muscle mass maintenance and growth require amino acids, nucleotides, and lipids for macromolecule and cell organelle synthesis. Some of these essential building blocks can be de novo synthesized from intermediates of the glycolysis in serine synthesis and pentose phosphate pathways. However, the knowledge of the importance of these metabolic pathways in muscle size regulation is poorly understood. The aim of this study was to identify enzymes from these metabolic pathways...     »
Dewey Decimal Classification:
500 Naturwissenschaften; 610 Medizin und Gesundheit
Book / Congress title:
INTERNATIONAL CONFERENCE ON CACHEXIA, SARCOPENIA ON CACHEXIA, SARCOPENIA & MUSCLE WASTING & MUSCLE WASTING
Organization:
Society on Cachexia, Sarcopenia & Muscle Wasting
Date of congress:
17-19 Juni in Stockholm
Publisher:
Journal of Cachexia, Sarcopenia and Muscle
Date of publication:
17.06.2023
Year:
2023
Quarter:
2. Quartal
Year / month:
2023-06
Month:
Jun
Pages:
167
Covered by:
Web of Science
Impact Factor:
12,036
Reviewed:
ja
Language:
en
Publication format:
WWW
Semester:
SS 23
TUM Institution:
Sportbiologie
Format:
Text
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