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- Titel:
Prognostic value of De Ritis ratio in patients with acute myocardial infarction.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Ndrepepa, Gjin; Holdenrieder, Stefan; Kastrati, Adnan
- Abstract:
- BACKGROUND: The association between aspartate aminotransferase to alanine aminotransferase ratio (De Ritis ratio) and prognosis of patients with acute myocardial infarction (AMI) remains poorly investigated. METHODS: This study included 3000 patients with AMI undergoing percutaneous coronary intervention. Patients were categorized in groups according to tertiles of the De Ritis ratio: tertile 1 (De Ritis ratio < 1.11; 905 patients), tertile 2 (De Ritis ratio 1.11 to 1.95; 1003 patients) and tertile 3 (De Ritis ratio > 1.95; 1002 patients). The primary endpoint was 3-year all-cause mortality. RESULTS: At 3 years, all-cause deaths occurred in 487 patients: 119 deaths (13.2%) in patients of 1st tertile, 164 deaths (17.8%) in patients of 2nd tertile and 204 deaths (21.9%) in patients of 3rd tertile of the De Ritis ratio (adjusted hazard ratio [HR] = 1.16, 95% confidence interval [CI] 1.02 to 1.31], P = 0.023 per unit increment in the logarithmic scale of the De Ritis ratio); cardiac deaths occurred in 328 patients: 76 deaths (8.2%) in patients of 1st tertile, 110 deaths (12.0%) in patients of 2nd tertile and 142 deaths (15.4%) in patients of 3rd tertile of the De Ritis ratio (adjusted HR = 1.20 [1.04-1.40], P = 0.014 per unit increment in the logarithmic scale of De Ritis ratio). The C-statistic of the multivariable model(s) with baseline data without and with De Ritis ratio was 0.822 [0.805-0.839] and 0.823 [0.805-0.840], (P = 0.419) for all-cause mortality and 0.831[0.811-0.852] and 0.832 [0.811-0.853], P = 0.621) for cardiac mortality. CONCLUSIONS: In patients with AMI, elevated De Ritis ratio was associated with increased risk of 3-year mortality.
- Zeitschriftentitel:
- Clin Chim Acta
- Jahr:
- 2022
- Band / Volume:
- 535
- Seitenangaben Beitrag:
- 75-81
- Volltext / DOI:
- doi:10.1016/j.cca.2022.08.016
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/35985502
- Print-ISSN:
- 0009-8981
- TUM Einrichtung:
- Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)
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