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Titel:

Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling.

Dokumenttyp:
Article; Journal Article
Autor(en):
Xiao, Yan; Petrucco, Luigi; Hoodless, Laura J; Portugues, Ruben; Czopka, Tim
Abstract:
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make m...     »
Zeitschriftentitel:
Nat Neurosci
Jahr:
2022
Band / Volume:
25
Heft / Issue:
3
Seitenangaben Beitrag:
280-284
Volltext / DOI:
doi:10.1038/s41593-022-01023-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35241802
Print-ISSN:
1097-6256
TUM Einrichtung:
Institut für Neurowissenschaften; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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