Wartewig, Tim;Daniels, Jay;Schulz, Miriam;Hameister, Erik;Joshi, Abhinav;Park, Joonhee;Morrish, Emma;Venkatasubramani, Anuroop V;Cernilogar, Filippo M;van Heijster, Frits H A;Hundshammer, Christian;Schneider, Heike;Konstantinidis, Filippos;Gabler, Judith V;Klement, Christine;Kurniawan, Henry;Law, Calvin;Lee, Yujin;Choi, Sara;Guitart, Joan;Forne, Ignasi;Giustinani, Jérôme;Müschen, Markus;Jain, Salvia;Weinstock, David M;Rad, Roland;Ortonne, Nicolas;Schilling, Franz;Schotta, Gunnar;Imhof, Axel;Brenner, Dirk;Choi, Jaehyuk;Ruland, Jürgen
PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.
Nat. Cancer
2023
4
10
1508-1525

Wang, Xiaobo;Istvanffy, Rouzanna;Ye, Linhan;Teller, Steffen;Laschinger, Melanie;Diakopoulos, Kalliope N;Görgülü, Kıvanç;Li, Qiaolin;Ren, Lei;Jäger, Carsten;Steiger, Katja;Muckenhuber, Alexander;Vilne, Baiba;Çifcibaşı, Kaan;Mota Reyes, Carmen;Yurteri, Ümmügülsüm;Kießler, Maximilian;Gürçınar, Ibrahim H;Sugden, Maya M;Yıldızhan, Saliha Elif;Sezerman, Osman Ugur;Çilingir, Sümeyye;Süyen, Güldal;Reichert, Maximilian;Schmid, Roland M;Bärthel, Stefanie;Öllinger, Rupert;Krüger, Achim;Rad, Roland;Saur, Dieter;Algül, Hana;Friess, Helmut;Lesina, Marina;Ceyhan, Güralp Onur;Demir, Ihsan Ekin
Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.
J Clin Invest
2023
133
21

Kotsiliti, Elena;Leone, Valentina;Schuehle, Svenja;Govaere, Olivier;Li, Hai;Wolf, Monika J;Horvatic, Helena;Bierwirth, Sandra;Hundertmark, Jana;Inverso, Donato;Zizmare, Laimdota;Sarusi-Portuguez, Avital;Gupta, Revant;O'Connor, Tracy;Giannou, Anastasios D;Shiri, Ahmad Mustafa;Schlesinger, Yehuda;Beccaria, Maria Garcia;Rennert, Charlotte;Pfister, Dominik;Öllinger, Rupert;Gadjalova, Iana;Ramadori, Pierluigi;Rahbari, Mohammad;Rahbari, Nuh;Healy, Marc;Fernández-Vaquero, Mirian;Yahoo, Neda;Janzen, Jakob;Singh, Indrabahadur;Fan, Chaofan;Liu, Xinyuan;Rau, Monika;Feuchtenberger, Martin;Schwaneck, Eva;Wallace, Sebastian J;Cockell, Simon;Wilson-Kanamori, John;Ramachandran, Prakash;Kho, Celia;Kendall, Timothy J;Leblond, Anne-Laure;Keppler, Selina J;Bielecki, Piotr;Steiger, Katja;Hofmann, Maike;Rippe, Karsten;Zitzlesberger, Horst;Weber, Achim;Malek, Nisar;Lüdde, Tom;Vucur, Mihael;Augustin, Hellmut G;Flavell, Richard;Parnas, Oren;Rad, Roland;Pabst, Olivier;Henderson, Neil C;Huber, Samuel;Macpherson, Andrew;Knolle, Percy;Claasen, Manfred;Geier, Andreas;Trautwein, Christoph;Unger, Kristian;Elinav, Eran;Waisman, Ari;Abdullah, Zeinab;Haller, Dirk;Tacke, Frank;Anstee, Quentin M;Heikenwalder, Mathias
Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling.
J Hepatol
2023
79
2
296-313

Bayerl, Felix;Meiser, Philippa;Donakonda, Sainitin;Hirschberger, Anna;Lacher, Sebastian B;Pedde, Anna-Marie;Hermann, Chris D;Elewaut, Anais;Knolle, Moritz;Ramsauer, Lukas;Rudolph, Thomas J;Grassmann, Simon;Öllinger, Rupert;Kirchhammer, Nicole;Trefny, Marcel;Anton, Martina;Wohlleber, Dirk;Höchst, Bastian;Zaremba, Anne;Krüger, Achim;Rad, Roland;Obenauf, Anna C;Schadendorf, Dirk;Zippelius, Alfred;Buchholz, Veit R;Schraml, Barbara U;Böttcher, Jan P
Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.
Immunity
2023
56
6
1341-1358.e11

Bredthauer, Carl;Fischer, Anja;Ahari, Ata Jadid;Cao, Xueqi;Weber, Julia;Rad, Lena;Rad, Roland;Wachutka, Leonhard;Gagneur, Julien
Transmicron: accurate prediction of insertion probabilities improves detection of cancer driver genes from transposon mutagenesis screens.
Nucleic Acids Res
2023
51
4

Götz, Viktoria;Qiao, Sen;Das, Debajyoti;Wartenberg, Philipp;Wyatt, Amanda;Wahl, Vanessa;Gamayun, Igor;Alasmi, Samer;Fecher-Trost, Claudia;Meyer, Markus R;Rad, Roland;Kaltenbacher, Thorsten;Kattler, Kathrin;Lipp, Peter;Becherer, Ute;Mollard, Patrice;Candlish, Michael;Boehm, Ulrich
Ovulation is triggered by a cyclical modulation of gonadotropes into a hyperexcitable state.
Cell Rep
2023
42
6

Paul, Mariel C;Schneeweis, Christian;Falcomatà, Chiara;Shan, Chuan;Rossmeisl, Daniel;Koutsouli, Stella;Klement, Christine;Zukowska, Magdalena;Widholz, Sebastian A;Jesinghaus, Moritz;Heuermann, Konstanze K;Engleitner, Thomas;Seidler, Barbara;Sleiman, Katia;Steiger, Katja;Tschurtschenthaler, Markus;Walter, Benjamin;Weidemann, Sören A;Pietsch, Regina;Schnieke, Angelika;Schmid, Roland M;Robles, Maria S;Andrieux, Geoffroy;Boerries, Melanie;Rad, Roland;Schneider, Günter;Saur, Dieter
Non-canonical functions of SNAIL drive context-specific cancer progression.
Nat Commun
2023
14
1

Fischer, Anja;Lersch, Robert;de Andrade Krätzig, Niklas;Strong, Alexander;Friedrich, Mathias J;Weber, Julia;Engleitner, Thomas;Öllinger, Rupert;Yen, Hsi-Yu;Kohlhofer, Ursula;Gonzalez-Menendez, Irene;Sailer, David;Kogan, Liz;Lahnalampi, Mari;Laukkanen, Saara;Kaltenbacher, Thorsten;Klement, Christine;Rezaei, Majdaddin;Ammon, Tim;Montero, Juan J;Schneider, Günter;Mayerle, Julia;Heikenwälder, Mathias;Schmidt-Supprian, Marc;Quintanilla-Martinez, Leticia;Steiger, Katja;Liu, Pentao;Cadiñanos, Juan;Vassiliou, George S;Saur, Dieter;Lohi, Olli;Heinäniemi, Merja;Conte, Nathalie;Bradley, Allan;Rad, Lena;Rad, Roland
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Cell Genom
2023
3
3

Bärthel, Stefanie;Falcomatà, Chiara;Rad, Roland;Theis, Fabian J;Saur, Dieter
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy.
Nat. Cancer
2023
4
4
454-467

Griger, Joscha;Widholz, Sebastian A;Jesinghaus, Moritz;de Andrade Krätzig, Niklas;Lange, Sebastian;Engleitner, Thomas;Montero, Juan José;Zhigalova, Ekaterina;Öllinger, Rupert;Suresh, Veveeyan;Winkler, Wiebke;Lier, Svenja;Baranov, Olga;Trozzo, Riccardo;Ben Khaled, Najib;Chakraborty, Shounak;Yu, Jiakun;Konukiewitz, Björn;Steiger, Katja;Pfarr, Nicole;Rajput, Ashish;Sailer, David;Keller, Gisela;Schirmacher, Peter;Röcken, Christoph;Fagerstedt, Klaus W;Mayerle, Julia;Schmidt-Supprian, Marc;Schneider, Günter;Weichert, Wilko;Calado, Dinis P;Sommermann, Thomas;Klöppel, Günter;Rajewsky, Klaus;Saur, Dieter;Rad, Roland
An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.
Cancer Cell
2023
41
7
1327-1344.e10