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Titel:

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P.

Dokumenttyp:
Journal Article
Autor(en):
Schwarz, Maria; Meyer, Caroline E; Löser, Alina; Lossow, Kristina; Hackler, Julian; Ott, Christiane; Jäger, Susanne; Mohr, Isabelle; Eklund, Ella A; Patel, Angana A H; Gul, Nadia; Alvarez, Samantha; Altinonder, Ilayda; Wiel, Clotilde; Maares, Maria; Haase, Hajo; Härtlova, Anetta; Grune, Tilman; Schulze, Matthias B; Schwerdtle, Tanja; Merle, Uta; Zischka, Hans; Sayin, Volkan I; Schomburg, Lutz; Kipp, Anna P
Abstract:
Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium and copper metabolism are inversely regulated, as increasing copper and decreasing selenium levels are observed in blood during aging and inflammation. Here we show that copper treatment increased intracellular selenium and SELENOP in hepatocytes and decreased extracellular SELENOP levels....     »
Zeitschriftentitel:
Nat Commun
Jahr:
2023
Band / Volume:
14
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-023-39245-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37311819
Print-ISSN:
2041-1723
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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