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Title:

Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis.

Document type:
Journal Article
Author(s):
Tschuck, Juliane; Theilacker, Lea; Rothenaigner, Ina; Weiß, Stefanie A I; Akdogan, Banu; Lam, Van Thanh; Müller, Constanze; Graf, Roman; Brandner, Stefanie; Pütz, Christian; Rieder, Tamara; Schmitt-Kopplin, Philippe; Vincendeau, Michelle; Zischka, Hans; Schorpp, Kenji; Hadian, Kamyar
Abstract:
Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. Recent research has identified many regulators that induce or inhibit ferroptosis; yet, many regulatory processes and networks remain to be elucidated. In this study, we performed a chemical genetics screen using small molecules with known mode of action and identified two agonists of the nuclear receptor Farnesoid X Receptor (FXR) that suppress ferroptosis, but not apoptosis or necroptosis. We de...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-42702-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37903763
Print-ISSN:
2041-1723
TUM Institution:
Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher)
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