User: Guest  Login
More Searchfields
Simple search
Title:

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P.

Document type:
Journal Article
Author(s):
Schwarz, Maria; Meyer, Caroline E; Löser, Alina; Lossow, Kristina; Hackler, Julian; Ott, Christiane; Jäger, Susanne; Mohr, Isabelle; Eklund, Ella A; Patel, Angana A H; Gul, Nadia; Alvarez, Samantha; Altinonder, Ilayda; Wiel, Clotilde; Maares, Maria; Haase, Hajo; Härtlova, Anetta; Grune, Tilman; Schulze, Matthias B; Schwerdtle, Tanja; Merle, Uta; Zischka, Hans; Sayin, Volkan I; Schomburg, Lutz; Kipp, Anna P
Abstract:
Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium and copper metabolism are inversely regulated, as increasing copper and decreasing selenium levels are observed in blood during aging and inflammation. Here we show that copper treatment increased intracellular selenium and SELENOP in hepatocytes and decreased extracellular SELENOP levels....     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-39245-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37311819
Print-ISSN:
2041-1723
TUM Institution:
Institut für Toxikologie und Umwelthygiene
 BibTeX