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Title:

A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rohwedder, Ina; Wackerbarth, Lou Martha; Heinig, Kristina; Ballweg, Annamaria; Altstätter, Johannes; Ripphahn, Myriam; Nussbaum, Claudia; Salvermoser, Melanie; Bierschenk, Susanne; Straub, Tobias; Gunzer, Matthias; Schmidt-Supprian, Marc; Kolben, Thomas; Schulz, Christian; Ma, Averil; Walzog, Barbara; Heinig, Matthias; Sperandio, Markus
Abstract:
Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with extrauterine life. By transcriptomic analysis of fetal and adult neutrophils, we shed new light on the molecular mechanisms of neutrophil maturation and functional adaption during fetal ontogeny. We identified an accumulation of differentially regulated genes within the noncanonical NF-κB signa...     »
Journal title abbreviation:
JCI Insight
Year:
2023
Journal volume:
8
Journal issue:
4
Fulltext / DOI:
doi:10.1172/jci.insight.155968
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36633909
Print-ISSN:
2379-3708
TUM Institution:
594; 611; Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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