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Title:

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment.

Document type:
Article; Journal Article
Author(s):
Falcomatà, Chiara; Bärthel, Stefanie; Widholz, Sebastian A; Schneeweis, Christian; Montero, Juan José; Toska, Albulena; Mir, Jonas; Kaltenbacher, Thorsten; Heetmeyer, Jeannine; Swietlik, Jonathan J; Cheng, Jing-Yuan; Teodorescu, Bianca; Reichert, Oliver; Schmitt, Constantin; Grabichler, Kathrin; Coluccio, Andrea; Boniolo, Fabio; Veltkamp, Christian; Zukowska, Magdalena; Vargas, Angelica Arenas; Paik, Woo Hyun; Jesinghaus, Moritz; Steiger, Katja; Maresch, Roman; Öllinger, Rupert; Ammon, Tim; Bara...     »
Abstract:
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like mesenchymal PDAC, which is driven by allelic imbalance, increased gene dosage and subsequent high expression levels of oncogenic KRAS, shows the most aggressive phenotype and strongest therapy resistance. In the present study, we performed a systematic high-throughput combination drug screen and identified a synergistic inter...     »
Journal title abbreviation:
Nat. Cancer
Year:
2022
Journal volume:
3
Journal issue:
3
Pages contribution:
318-336
Fulltext / DOI:
doi:10.1038/s43018-021-00326-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35122074
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie; Lehrstuhl für Translationale Tumorforschung (DKTK) (Prof. Saur); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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