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Title:

Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer.

Document type:
Journal Article
Author(s):
Falcomata, Chiara; Barthel, Stefanie; Ulrich, Angelika; Diersch, Sandra; Veltkamp, Christian; Rad, Lena; Boniolo, Fabio; Solar, Myriam; Steiger, Katja; Seidler, Barbara; Zukowska, Magdalena; Madej, Joanna; Wang, Mingsong; Ollinger, Rupert; Maresch, Roman; Barenboim, Maxim; Eser, Stefan; Tschurtschenthaler, Markus; Mehrabi, Arianeb; Roessler, Stephanie; Goeppert, Benjamin; Kind, Alexander; Schnieke, Angelika; Robles, Maria S; Bradley, Allan; Schmid, Roland M; Schmidt-Supprian, Marc; Reichert, Max...     »
Abstract:
Biliary tract cancer ranks among the most lethal human malignancies, representing an unmet clinical need. Its abysmal prognosis is tied to an increasing incidence and a fundamental lack of mechanistic knowledge regarding the molecular basis of the disease. Here, we show that the Pdx1-positive extrahepatic biliary epithelium is highly susceptible toward transformation by activated PIK3CAH1047R but refractory to oncogenic KrasG12D. Using genome-wide transposon screens and genetic loss-of-function...     »
Journal title abbreviation:
Cancer Discov
Year:
2021
Journal volume:
11
Journal issue:
12
Pages contribution:
3158-3177
Fulltext / DOI:
doi:10.1158/2159-8290.CD-21-0209
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34282029
Print-ISSN:
2159-8274
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie; Klinik und Poliklinik für Kinder- und Jugendmedizin; Lehrstuhl für Translationale Tumorforschung (DKTK) (Prof. Saur); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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