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Titel:

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer.

Dokumenttyp:
Review; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Falcomatà, Chiara; Bärthel, Stefanie; Schneider, Günter; Rad, Roland; Schmidt-Supprian, Marc; Saur, Dieter
Abstract:
UNLABELLED: Immunotherapies have shown benefits across a range of human cancers, but not pancreatic ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive tumor microenvironment (TME) constitutes an important roadblock to their efficacy. The landscape of the TME differs substantially across PDAC subtypes, indicating context-specific principles of immunosuppression. In this review, we discuss how PDAC cells, the local TME, and systemic host and environmental factors dri...     »
Zeitschriftentitel:
Cancer Discov
Jahr:
2023
Band / Volume:
13
Heft / Issue:
2
Seitenangaben Beitrag:
278-297
Volltext / DOI:
doi:10.1158/2159-8290.CD-22-0876
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36622087
Print-ISSN:
2159-8274
TUM Einrichtung:
Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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