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Titel:

In vivo neutralization of colchicine toxicity by a PASylated anticalin in a rat model.

Dokumenttyp:
Journal Article
Autor(en):
Jerschke, Elena; Barkovsky, Mikhail; Jung, Nicole; Neuberger, Heidi; Stenzel, Jochen; Eyer, Florian; Skerra, Arne; Geith, Stefanie
Abstract:
We have investigated the pharmacokinetics (PK) and in vivo activity of an Anticalin exhibiting picomolar affinity towards colchicine, a plant toxin with low tolerable dose in humans. PK analysis of the 20-kDa "Colchicalin" protein in male Sprague Dawley rats (n = 3) revealed a very short plasma half-life (3.5 min), which was prolonged 21-fold via genetic fusion with a 200-residue Pro/Ala sequence (PASylation). The scavenging activity of the PASylated Colchicalin was investigated over 3.5 h via s...     »
Zeitschriftentitel:
Toxicology
Jahr:
2023
Band / Volume:
492
Volltext / DOI:
doi:10.1016/j.tox.2023.153526
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37116682
Print-ISSN:
0300-483X
TUM Einrichtung:
Abteilung für Toxikologie (Prof. Eyer)
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