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Title:

Pressure- and time-dependent alveolar recruitment/derecruitment in a spatially resolved patient-specific computational model for injured human lungs

Document type:
Zeitschriftenaufsatz
Author(s):
Carolin M. Geitner, Lea J. Köglmeier, Inéz Frerichs, Patrick Langguth, Matthias Lindner, Dirk Schädler, Norbert Weiler, Tobias Becher, Wolfgang A. Wall
Abstract:
We present a novel computational model for the dynamics of alveolar recruitment/derecruitment (RD), which reproduces the underlying characteristics typically observed in injured lungs. The basic idea is a pressure- and time-dependent variation of the stress-free reference volume in reduced dimensional viscoelastic elements representing the acinar tissue. We choose a variable reference volume triggered by critical opening and closing pressures in a time-dependent manner from a straightforward mec...     »
Keywords:
alveolar strain, ARDS, digital twin, lung modeling, recruitment, reduceddimensional, VILI
Journal title:
International Journal for Numerical Methods in Biomedical Engineering
Year:
2023
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1002/cnm.3787
Status:
Verlagsversion / published
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