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Title:

Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment

Document type:
Zeitschriftenaufsatz
Author(s):
Silvia Hervas-Raluy, Barbara Wirthl, Pedro E. Guerrero, Gil Robalo Rei, Jonas Nitzler, Esther Coronado, Jaime Font de Mora Sainz, Bernhard A. Schrefler, Maria Jose Gomez-Benito, Jose Manuel Garcia-Aznar, Wolfgang A. Wall
Abstract:
To unravel processes that lead to the growth of solid tumours, it is necessary to link knowledge of cancer biology with the physical properties of the tumour and its interaction with the surrounding microenvironment. Our understanding of the underlying mechanisms is however still imprecise. We therefore developed computational physics-based models, which incorporate the interaction of the tumour with its surroundings based on the theory of porous media. However, the experimental validation of su...     »
Journal title:
Computers in Biology and Medicine
Year:
2023
Year / month:
2023-04
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.compbiomed.2023.106895
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