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Title:

How to design a low-cost pilot scale magnetic bioseparation process for protein separation from complex mixtures using in-line process analytics

Document type:
Zeitschriftenaufsatz
Author(s):
Krolitzki E; Steck S; Nazifi A; Abt M; Schwaminger SP; Berensmeier S
Abstract:
Magnetic separation is a powerful tool for the integrated capture and purification of biomolecules and cells directly from complex feed media without the need for prior clarification and without the risk of equipment blockage. In this study, we equipped a commercially available rotor–stator high-gradient magnetic separator (RS-HGMS) with in-line analytics of hygienic design (absorbance, conductivity, pH, and flow) and used it for a systematic characterization of the equipment. By combining parti...     »
Keywords:
Magnetic separation; Bioseparation; Protein purification; Capture; Iron oxide nanoparticles; Lactoferrin
Journal title:
Separation and Purification Technology
Year:
2023
Journal volume:
323
Year / month:
2023-10
Pages contribution:
124429
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.seppur.2023.124429
WWW:
https://www.sciencedirect.com/science/article/pii/S1383586623013370
Publisher:
Elsevier BV
Print-ISSN:
13835866
E-ISSN:
1383-5866
Impact Factor:
9.1
Accepted:
24.06.2023
Date of publication:
27.06.2023
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