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Titel:

Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy.

Dokumenttyp:
Journal Article; Review; Research Support, Non-U.S. Gov't
Autor(en):
Bärthel, Stefanie; Falcomatà, Chiara; Rad, Roland; Theis, Fabian J; Saur, Dieter
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a heterogeneous genetic landscape and an immunosuppressive tumor microenvironment. Recent advances in high-resolution single-cell sequencing and spatial transcriptomics technologies have enabled an in-depth characterization of both malignant and host cell types and increased our understanding of the heterogeneity and plasticity of PDAC in the steady state and under therapeutic perturbation. In this Review w...     »
Zeitschriftentitel:
Nat. Cancer
Jahr:
2023
Band / Volume:
4
Heft / Issue:
4
Seitenangaben Beitrag:
454-467
Volltext / DOI:
doi:10.1038/s43018-023-00526-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36959420
TUM Einrichtung:
Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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