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Titel:

Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism.

Dokumenttyp:
Journal Article
Autor(en):
Knoop, Paul; Yilmaz, Dilay; Paganoni, Rossana; Steele-Perkins, Peter; Gruber, Andreas; Akdogan, Banu; Zischka, Hans; Leopold, Kerstin; Vujić Spasić, Maja
Abstract:
Mutations in the HFE/Hfe gene cause Hereditary Hemochromatosis (HH), a highly prevalent genetic disorder characterized by elevated iron deposition in multiple tissues. HFE acts in hepatocytes to control hepcidin expression, whereas HFE actions in myeloid cells are required for cell-autonomous and systemic iron regulation in aged mice. To address the role of HFE specifically in liver-resident macrophages, we generated mice with a selective Hfe deficiency in Kupffer cells (HfeClec4fCre). The analy...     »
Zeitschriftentitel:
Int J Mol Sci
Jahr:
2023
Band / Volume:
24
Heft / Issue:
10
Volltext / DOI:
doi:10.3390/ijms24108948
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37240294
Print-ISSN:
1422-0067
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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