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Titel:

Green Tea Extract to Prevent Colorectal Adenomas, Results of a Randomized, Placebo-Controlled Clinical Trial.

Dokumenttyp:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Autor(en):
Seufferlein, Thomas; Ettrich, Thomas J; Menzler, Stefan; Messmann, Helmut; Kleber, Gerhard; Zipprich, Alexander; Frank-Gleich, Stefanie; Algül, Hana; Metter, Klaus; Odemar, Frank; Heuer, Theodor; Hügle, Ulrich; Behrens, Rüdiger; Berger, Andreas W; Scholl, Catharina; Schneider, Katharina L; Perkhofer, Lukas; Rohlmann, Friederike; Muche, Rainer; Stingl, Julia C
Abstract:
INTRODUCTION: Preclinical, epidemiological, and small clinical studies suggest that green tea extract (GTE) and its major active component epigallocatechingallate (EGCG) exhibit antineoplastic effects in the colorectum. METHODS: A randomized, double-blind trial of GTE standardized to 150 mg of EGCG b.i.d. vs placebo over 3 years was conducted to prevent colorectal adenomas (n = 1,001 with colon adenomas enrolled, 40 German centers). Randomization (1:1, n = 879) was performed after a 4-week run-i...     »
Zeitschriftentitel:
Am J Gastroenterol
Jahr:
2022
Band / Volume:
117
Heft / Issue:
6
Seitenangaben Beitrag:
884-894
Volltext / DOI:
doi:10.14309/ajg.0000000000001706
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35213393
Print-ISSN:
0002-9270
TUM Einrichtung:
273; Lehrstuhl für Tumormetabolismus (Prof. Algül)
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