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Title:

Genetic Analysis of the ATG16L1 c.898A>G (p.T300A) Variant in Acute and Chronic Pancreatitis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Neubauer, Claudia; Ewers, Maren; Schulz, Hans-Ulrich; Weiß, Frank Ulrich; Lämmerhirt, Felix; Lerch, Markus M; Bugert, Peter; Landt, Olfert; Algül, Hana; Rosendahl, Jonas; Witt, Heiko
Abstract:
OBJECTIVES: Human and animal studies suggest an important role of autophagy in the pathogenesis of pancreatitis. ATG16L1 (autophagy-related 16 like 1) is part of a protein complex that is involved in the formation of autophagosomes. The c.898A > G (p.T300A) variant of ATG16L1 is associated with Crohn disease. In this study, we analyzed ATG16L1 c.898A > G (p.T300A) for an association with pancreatitis. METHODS: We genotyped 777 patients and 551 control subjects of German origin by melting curve a...     »
Journal title abbreviation:
Pancreas
Year:
2022
Journal volume:
51
Journal issue:
9
Pages contribution:
1231-1234
Fulltext / DOI:
doi:10.1097/MPA.0000000000002177
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37078950
Print-ISSN:
0885-3177
TUM Institution:
Lehrstuhl für Tumormetabolismus (Prof. Algül)
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