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Titel:

In vivo dynamics and anti-tumor effects of EpCAM-directed CAR T-cells against brain metastases from lung cancer.

Dokumenttyp:
Journal Article
Autor(en):
Xu, Tao; Karschnia, Philipp; Cadilha, Bruno Loureiro; Dede, Sertac; Lorenz, Michael; Seewaldt, Niklas; Nikolaishvili, Elene; Müller, Katharina; Blobner, Jens; Teske, Nico; Herold, Julika J; Rejeski, Kai; Langer, Sigrid; Obeck, Hannah; Lorenzini, Theo; Mulazzani, Matthias; Zhang, Wenlong; Ishikawa-Ankerhold, Hellen; Buchholz, Veit R; Subklewe, Marion; Thon, Niklas; Straube, Andreas; Tonn, Joerg-Christian; Kobold, Sebastian; von Baumgarten, Louisa
Abstract:
Lung cancer patients are at risk for brain metastases and often succumb to their intracranial disease. Chimeric Antigen Receptor (CAR) T-cells emerged as a powerful cell-based immunotherapy for hematological malignancies; however, it remains unclear whether CAR T-cells represent a viable therapy for brain metastases. Here, we established a syngeneic orthotopic cerebral metastasis model in mice by combining a chronic cranial window with repetitive intracerebral two-photon laser scanning-microsco...     »
Zeitschriftentitel:
Oncoimmunology
Jahr:
2023
Band / Volume:
12
Heft / Issue:
1
Volltext / DOI:
doi:10.1080/2162402X.2022.2163781
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36687005
Print-ISSN:
2162-4011
TUM Einrichtung:
608; 617; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
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