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Title:

Activation-inducible CAR expression enables precise control over engineered CAR T cell function.

Document type:
Journal Article
Author(s):
Fraessle, Simon P; Tschulik, Claudia; Effenberger, Manuel; Cletiu, Vlad; Gerget, Maria; Schober, Kilian; Busch, Dirk H; Germeroth, Lothar; Stemberger, Christian; Poltorak, Mateusz P
Abstract:
CAR T cell therapy is a rapidly growing area of oncological treatments having a potential of becoming standard care for multiple indications. Coincidently, CRISPR/Cas gene-editing technology is entering next-generation CAR T cell product manufacturing with the promise of more precise and more controllable cell modification methodology. The intersection of these medical and molecular advancements creates an opportunity for completely new ways of designing engineered cells to help overcome current...     »
Journal title abbreviation:
Commun Biol
Year:
2023
Journal volume:
6
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s42003-023-04978-w
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37277433
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
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