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Title:

Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer.

Document type:
Journal Article
Author(s):
Jaitner, Stefanie; Pretzsch, Elise; Neumann, Jens; Schäffauer, Achim; Schiemann, Matthias; Angele, Martin; Kumbrink, Jörg; Schwitalla, Sarah; Greten, Florian R; Brandl, Lydia; Klauschen, Frederick; Horst, David; Kirchner, Thomas; Jung, Andreas
Abstract:
Tumor stem cells play a pivotal role in carcinogenesis and metastatic spread in colorectal cancer (CRC). Olfactomedin 4 (OLFM4) is co-expressed with the established stem cell marker leucine-rich repeat-containing G protein-coupled receptor 5 at the bottom of intestinal crypts and has been suggested as a surrogate for cancer stemness and a biomarker in gastrointestinal tumors associated with prognosis. Therefore, it was the aim of the present study to clarify whether OLFM4 is involved in carcinog...     »
Journal title abbreviation:
J Pathol Clin Res
Year:
2023
Journal volume:
9
Journal issue:
1
Pages contribution:
73-85
Fulltext / DOI:
doi:10.1002/cjp2.300
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36349502
TUM Institution:
591; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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