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Titel:

RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.

Dokumenttyp:
Journal Article
Autor(en):
Kuhn, Laura B; Valentin, Stefanie; Stojanovic, Kristina; Strobl, Daniel C; Babushku, Tea; Wang, Yan; Rambold, Ursula; Scheffler, Laura; Grath, Sonja; John-Robbert, Dorothy; Blum, Helmut; Feuchtinger, Annette; Blutke, Andreas; Weih, Falk; Kitamura, Daisuke; Rad, Roland; Strobl, Lothar J; Zimber-Strobl, Ursula
Abstract:
Activation of CD40-signaling contributes to the initiation, progression and drug resistance of B cell lymphomas. We contributed to this knowledge by showing that constitutive CD40-signaling in B cells induces B cell hyperplasia and finally B cell lymphoma development in transgenic mice. CD40 activates, among others, the non-canonical NF-ĸB signaling, which is constitutively activated in several human B cell lymphomas and is therefore presumed to contribute to lymphopathogenesis. This prompted us...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2022
Band / Volume:
13
Volltext / DOI:
doi:10.3389/fimmu.2022.913275
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36110848
Print-ISSN:
1664-3224
TUM Einrichtung:
Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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