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Titel:

[Effect of low-dose PDT on perfusion of the choriocapillaris in cCSCR : An OCT-angiography-based study].

Dokumenttyp:
English Abstract; Journal Article
Autor(en):
Reifeltshammer, E; Feucht, N; Lohmann, C P; Maier, M
Abstract:
BACKGROUND: In patients with chronic central serous chorioretinopathy (cCSCR) it is assumed that low-dose photodynamic therapy (PDT) induces short-term hypoperfusion of the choriocapillaris, which leads to long-term choroidal vascular remodeling and subsequent reduction of vascular hyperpermeability and leakage; however, it remains unclear whether the hypoperfusion completely returns to normal. The main aim of the retrospective study was to analyze the choroidal flow signal after treatment with low-dose PDT by optical coherence tomography-angiography (OCT‑A). PATIENTS AND METHODS: In this study 16 eyes with a total of 19 treated areas were included. Aside from visual acuity and metamorphopsia checks, all patients underwent enhanced depth imaging-OCT (EDI-OCT) and OCT‑A in the areas treated with low-dose PDT. In the present study, the flow signal in the choriocapillaris and choroidal thickness were measured retrospectively both in the PDT-treated area and in a non-treated reference area located in close proximity with similar eccentricity to the center of the fovea. RESULTS: The study found a mean reduction of 33% (p < 0.001) of the choroidal flow signal in the treated area compared to the reference area and an average decrease in choroidal thickness of 71 µm (p = 0.001). In the long term 7 out of 10 patients suffered from metamorphopsia despite the low-dose PDT; however, visual acuity was improved in almost half of the patients by the treatment. CONCLUSION: Using OCT‑A it could be shown that at the choriocapillaris level, hypoperfusion persists in spite of low-dose PDT. Thus, the choroidal vascular remodeling is not able to completely compensate for the hypoperfusion induced by thrombosis.
Zeitschriftentitel:
Ophthalmologe
Jahr:
2022
Band / Volume:
119
Heft / Issue:
7
Seitenangaben Beitrag:
699-704
Volltext / DOI:
doi:10.1007/s00347-021-01552-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34936026
Print-ISSN:
0941-293X
TUM Einrichtung:
Klinik und Poliklinik für Augenheilkunde
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