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Titel:

Combined PARP1-Targeted Nuclear Contrast and Reflectance Contrast Enhance Confocal Microscopic Detection of Basal Cell Carcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Sahu, Aditi; Cordero, Jose; Wu, Xiancheng; Kossatz, Susanne; Harris, Ucalene; Demetrio Desouza Franca, Paula; Kurtansky, Nicholas R; Everett, Niasia; Dusza, Stephen; Monnier, Jilliana; Kumar, Piyush; Alessi-Fox, Christi; Brand, Christian; Roberts, Sheryl; Kose, Kivanc; Phillip, William; Lee, Erica; Jason Chen, Chih-Shan; Rossi, Anthony; Nehal, Kishwer; Pulitzer, Melissa; Longo, Caterina; Halpern, Allan; Reiner, Thomas; Rajadhyaksha, Milind; Jain, Manu
Abstract:
Reflectance confocal microscopy (RCM) with endogenous backscattered contrast can noninvasively image basal cell carcinomas (BCCs) in skin. However, BCCs present with high nuclear density, and the relatively weak backscattering from nuclei imposes a fundamental limit on contrast, detectability, and diagnostic accuracy. We investigated PARPi-FL, an exogenous nuclear poly(adenosine diphosphate ribose) polymerase (PARP1)-targeted fluorescent contrast agent, and fluorescence confocal microscopy towar...     »
Zeitschriftentitel:
J Nucl Med
Jahr:
2022
Band / Volume:
63
Heft / Issue:
6
Seitenangaben Beitrag:
912-918
Volltext / DOI:
doi:10.2967/jnumed.121.262600
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34649941
Print-ISSN:
0161-5505
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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