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- Title:
Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease.
- Document type:
- Journal Article
- Author(s):
- Won, Ki-Bum; Park, Hyung-Bok; Heo, Ran; Lee, Byoung Kwon; Lin, Fay Y; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Gonçalves, Pedro de Araújo; Leipsic, Jonathon A; Lee, Sang-Eun; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Berman, Daniel S; Narula, Jagat; Bax, Jeroen J; Min, James K; Chang, Hyuk-Jae
- Abstract:
- BACKGROUND: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain ) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. HYPOTHESIS: Normal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. METHODS: We analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBPmaintain (follow-up SBP < 120 mm Hg) and ≥elevated SBPmaintain (follow-up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period. RESULTS: Compared to participants with normal SBPmaintain , those with ≥elevated SBPmaintain had higher annualized total PVC (mm3 /year) (0.0 [0.0-2.2] vs. 4.1 [0.0-13.0]; p < .001). Baseline total plaque volume (β = .10) and the levels of SBPmaintain (β = .23) and follow-up high-density lipoprotein cholesterol (β = -0.28) were associated with annualized total PVC (all p < .05). The optimal cutoff of SBPmaintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59-0.81; p < .05). SBPmaintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51-10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01-1.06) independently influenced coronary plaque progression (all p < .05). CONCLUSION: Normal SBPmaintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease.
- Journal title abbreviation:
- Clin Cardiol
- Year:
- 2022
- Journal volume:
- 45
- Journal issue:
- 8
- Pages contribution:
- 873-881
- Fulltext / DOI:
- doi:10.1002/clc.23870
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/35673995
- Print-ISSN:
- 0160-9289
- TUM Institution:
- Institut für Radiologie und Nuklearmedizin
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