Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels.

Won, Ki-Bum; Lee, Byoung Kwon; Heo, Ran; Park, Hyung-Bok; Lin, Fay Y; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; de Araújo Gonçalves, Pedro; Leipsic, Jonathon A; Lee, Sang-Eun; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Berman, Daniel S; Narula, Jagat; Bax, Jeroen J; Min, James K; Chang, Hyuk-Jae

doi:10.1016/j.jacasi.2021.10.010

2022

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Title:: Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels.
Document type:: Journal Article
Author(s):: Won, Ki-Bum; Lee, Byoung Kwon; Heo, Ran; Park, Hyung-Bok; Lin, Fay Y; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; de Araújo Gonçalves, Pedro; Leipsic, Jonathon A; Lee, Sang-Eun; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Berman, Daniel S; Narula, Jagat; Bax, Jeroen J; Min, James K; Chang, Hyuk-Jae
Abstract:: BACKGROUND: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. OBJECTIVES: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). METHODS: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period. RESULTS: Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = -0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = -2.401; P = 0.004). CONCLUSIONS: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels. (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging [PARADIGM]; NCT02803411).
Year:: 2022
Journal volume:: 2
Journal issue:: 3
Pages contribution:: 311-319
Fulltext / DOI:: doi:10.1016/j.jacasi.2021.10.010
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/36338409
TUM Institution:: Institut für Radiologie und Nuklearmedizin
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mediaTUM Gesamtbestand Hochschulbibliographie 2022 Schools und Fakultäten Medizin Institut für Radiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Institut für Radiologie und Nuklearmedizin 2022