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Title:

In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors.

Document type:
Article; Journal Article
Author(s):
Song, Beomjong; Kang, Chan Young; Han, Jun Hee; Kano, Masanobu; Konnerth, Arthur; Bae, Sangsu
Abstract:
Gene manipulation is a useful approach for understanding functions of genes and is important for investigating basic mechanisms of brain function on the level of single neurons and circuits. Despite the development and the wide range of applications of CRISPR-Cas9 and base editors (BEs), their implementation for an analysis of individual neurons in vivo remained limited. In fact, conventional gene manipulations are generally achieved only on the population level. Here, we combined either CRISPR-...     »
Journal title abbreviation:
Comput Struct Biotechnol J
Year:
2021
Journal volume:
19
Pages contribution:
2477-2485
Fulltext / DOI:
doi:10.1016/j.csbj.2021.04.051
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34025938
TUM Institution:
Institut für Neurowissenschaften
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