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Titel:

In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors.

Dokumenttyp:
Article; Journal Article
Autor(en):
Song, Beomjong; Kang, Chan Young; Han, Jun Hee; Kano, Masanobu; Konnerth, Arthur; Bae, Sangsu
Abstract:
Gene manipulation is a useful approach for understanding functions of genes and is important for investigating basic mechanisms of brain function on the level of single neurons and circuits. Despite the development and the wide range of applications of CRISPR-Cas9 and base editors (BEs), their implementation for an analysis of individual neurons in vivo remained limited. In fact, conventional gene manipulations are generally achieved only on the population level. Here, we combined either CRISPR-...     »
Zeitschriftentitel:
Comput Struct Biotechnol J
Jahr:
2021
Band / Volume:
19
Seitenangaben Beitrag:
2477-2485
Volltext / DOI:
doi:10.1016/j.csbj.2021.04.051
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34025938
TUM Einrichtung:
Institut für Neurowissenschaften
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