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Title:

Resting-state BOLD functional connectivity depends on the heterogeneity of capillary transit times in the human brain A combined lesion and simulation study about the influence of blood flow response timing.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schneider, Sebastian C; Archila-Meléndez, Mario E; Göttler, Jens; Kaczmarz, Stephan; Zott, Benedikt; Priller, Josef; Kallmayer, Michael; Zimmer, Claus; Sorg, Christian; Preibisch, Christine
Abstract:
Functional connectivity (FC) derived from blood oxygenation level dependent (BOLD) functional magnetic resonance imaging at rest (rs-fMRI), is commonly interpreted as indicator of neuronal connectivity. In a number of brain disorders, however, metabolic, vascular, and hemodynamic impairments can be expected to alter BOLD-FC independently from neuronal activity. By means of a neurovascular coupling (NVC) model of BOLD-FC, we recently demonstrated that aberrant timing of cerebral blood flow (CBF)...     »
Journal title abbreviation:
Neuroimage
Year:
2022
Journal volume:
255
Fulltext / DOI:
doi:10.1016/j.neuroimage.2022.119208
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35427773
Print-ISSN:
1053-8119
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie (Prof. Priller); Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie (Prof. Eckstein); Professur für Neuroradiologie (Prof. Zimmer)
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