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Titel:

IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Schröder, Alexandra; Lunding, Lars P; Zissler, Ulrich M; Vock, Christina; Webering, Sina; Ehlers, Johanna C; Orinska, Zane; Chaker, Adam; Schmidt-Weber, Carsten B; Lang, Niklas J; Schiller, Herbert B; Mall, Marcus A; Fehrenbach, Heinz; Dinarello, Charles A; Wegmann, Michael
Abstract:
BACKGROUND: Children with asthma have impaired production of interleukin (IL) 37; in mice, IL-37 reduces hallmarks of experimental allergic asthma (EAA). However, it remains unclear how IL-37 exerts its inhibitory properties in asthma. This study aimed to identify the mechanism(s) by which IL-37 controls allergic inflammation. METHODS: IL-37 target cells were identified by single-cell RNA-seq of IL-1R5 and IL-1R8. Airway tissues were isolated by laser-capture microdissection and examined by mic...     »
Zeitschriftentitel:
Allergy
Jahr:
2022
Band / Volume:
77
Heft / Issue:
3
Seitenangaben Beitrag:
856-869
Volltext / DOI:
doi:10.1111/all.15072
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34460953
Print-ISSN:
0105-4538
TUM Einrichtung:
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg); Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber)
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