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Title:

CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation.

Document type:
Journal Article
Author(s):
Benkhoucha, Mahdia; Tran, Ngoc Lan; Breville, Gautier; Senoner, Isis; Bradfield, Paul F; Papayannopoulou, Thalia; Merkler, Doron; Korn, Thomas; Lalive, Patrice H
Abstract:
OBJECTIVE: c-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate cell migration, maturation, cytokine production, and antigen presentation. Here, we report that CD4+c-Met+ T cells are detected at increased levels in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). METHODS: c-Met expression by CD4+ T cells was analyzed mostly by flow cytometry and by immunohistochemistry fr...     »
Journal title abbreviation:
J Neuroinflammation
Year:
2022
Journal volume:
19
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s12974-022-02461-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35488271
Print-ISSN:
1742-2094
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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