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Title:

Global koff -rates of polyclonal T-cell populations merge subclonal avidities and predict functionality.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lückemeier, Philipp; Molter, Katherine L; Jarosch, Sebastian; Huppertz, Patrick; Purcarea, Anna; Effenberger, Manuel J P; Nauerth, Magdalena; D'Ippolito, Elvira; Schober, Kilian; Busch, Dirk H
Abstract:
The avidity of TCRs for peptide-major histocompatibility complexes (pMHCs) is a governing factor in how T cells respond to antigen. TCR avidity is generally linked to T-cell functionality and there is growing evidence for distinct roles of low and high avidity T cells in different phases of immune responses. While physiological immune responses and many therapeutic T-cell products targeting infections or cancers consist of polyclonal T-cell populations with a wide range of individual avidities,...     »
Journal title abbreviation:
Eur J Immunol
Year:
2022
Journal volume:
52
Journal issue:
4
Pages contribution:
582-596
Fulltext / DOI:
doi:10.1002/eji.202149597
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35099805
Print-ISSN:
0014-2980
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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