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Titel:

Functional antagonism between CagA and DLC1 in gastric cancer.

Dokumenttyp:
Journal Article
Autor(en):
Hinsenkamp, Isabel; Köhler, Jan P; Flächsenhaar, Christoph; Hitkova, Ivana; Meessen, Sabine Eberhart; Gaiser, Timo; Wieland, Thomas; Weiss, Christel; Röcken, Christoph; Mowat, Michael; Quante, Michael; Taxauer, Karin; Mejias-Luque, Raquel; Gerhard, Markus; Vogelmann, Roger; Meindl-Beinker, Nadja; Ebert, Matthias; Burgermeister, Elke
Abstract:
Helicobacter (H.) pylori-induced gastritis is a risk factor for gastric cancer (GC). Deleted-in-liver-cancer-1 (DLC1/ARHGAP7) inhibits RHOA, a downstream mediator of virulence factor cytotoxin-A (CagA) signalling and driver of consensus-molecular-subtype-2 diffuse GC. DLC1 located to enterochromaffin-like and MIST1+ stem/chief cells in the stomach. DLC1+ cells were reduced in H. pylori gastritis and GC, and in mice infected with H. pylori. DLC1 positivity inversely correlated with tumour progres...     »
Zeitschriftentitel:
Cell Death Discov
Jahr:
2022
Band / Volume:
8
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41420-022-01134-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35963849
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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