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Title:

T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer.

Document type:
Journal Article
Author(s):
Xue, Busheng; von Heyking, Kristina; Gassmann, Hendrik; Poorebrahim, Mansour; Thiede, Melanie; Schober, Kilian; Mautner, Josef; Hauer, Julia; Ruland, Jürgen; Busch, Dirk H; Thiel, Uwe; Burdach, Stefan E G
Abstract:
Ewing sarcoma (EwS) is a highly malignant sarcoma of bone and soft tissue with early metastatic spread and an age peak in early puberty. The prognosis in advanced stages is still dismal, and the long-term effects of established therapies are severe. Efficacious targeted therapies are urgently needed. Our previous work has provided preliminary safety and efficacy data utilizing T cell receptor (TCR) transgenic T cells, generated by retroviral gene transfer, targeting HLA-restricted peptides on th...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2022
Journal volume:
14
Journal issue:
22
Fulltext / DOI:
doi:10.3390/cancers14225485
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36428578
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer)
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