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Titel:

Comprehensive analysis of immune responses in CLL patients after heterologous COVID-19 vaccination.

Dokumenttyp:
Preprint
Autor(en):
Lee, Hye Kyung; Hoechstetter, Manuela A; Buchner, Maike; Pham, Trang Thu; Huh, Jin Won; Müller, Katharina; Zange, Sabine; von Buttlar, Heiner; Girl, Philipp; Wölfel, Roman; Brandmeier, Lisa; Pfeuffer, Lisa; Furth, Priscilla A; Wendtner, Clemens-Martin; Hennighausen, Lothar
Abstract:
Patients with chronic lymphocytic leukemia (CLL) treated with B-cell pathway inhibitors and anti-CD20 antibodies exhibit low humoral response rate (RR) following SARS-CoV-2 vaccination. To investigate the relationship between the initial transcriptional response to vaccination with ensuing B and T cell immune responses, we performed a comprehensive immune transcriptome analysis flanked by antibody and T cell assays in peripheral blood prospectively collected from 15 CLL/SLL patients vaccinated w...     »
Zeitschriftentitel:
medRxiv
Jahr:
2022
Volltext / DOI:
doi:10.1101/2022.09.21.22280205
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36172132
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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