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Title:

CXCR3 and Cognate Ligands are Associated with Immune Cell Alteration and Aggressiveness of Pancreatic Ductal Adenocarcinoma.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural
Author(s):
Cannon, Andrew; Thompson, Christopher M; Maurer, H Carlo; Atri, Pranita; Bhatia, Rakesh; West, Sean; Ghersi, Dario; Olive, Kenneth P; Kumar, Sushil; Batra, Surinder K
Abstract:
PURPOSE: The cytokine milieu in pancreatic ductal adenocarcinoma (PDAC) promotes tumor progression and immune suppression, contributing to the dismal prognosis of patients with PDAC. The roles of many of these cytokines, however, have not been thoroughly investigated in PDAC. EXPERIMENTAL DESIGN: PDAC microarray and The Cancer Genome Atlas datasets were analyzed to identify cytokines and cognate receptors overexpressed in PDAC and associated with survival. Pathway and CIBERSORT analyses were use...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2020
Journal volume:
26
Journal issue:
22
Pages contribution:
6051-6063
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-20-1359
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32873571
Print-ISSN:
1078-0432
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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