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Titel:

Generation of An Endogenous FGFR2-BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells.

Dokumenttyp:
Journal Article
Autor(en):
Reicher, Andreas; Harris, Antoneicka L; Prinz, Felix; Kiesslich, Tobias; Wei, Miaoyan; Öllinger, Rupert; Rad, Roland; Pichler, Martin; Kwong, Lawrence N
Abstract:
Fibroblast growth factor receptor 2 (FGFR2) gene fusions are bona fide oncogenic drivers in 10-15% of intrahepatic cholangiocarcinoma (CCA), yet currently there are no cell lines publically available to study endogenous FGFR2 gene fusions. The ability of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 to generate large yet precise chromosomal rearrangements has presented the possibility of engineering endogenous gene fusions for downstream studies. In this technical repor...     »
Zeitschriftentitel:
Int J Mol Sci
Jahr:
2020
Band / Volume:
21
Heft / Issue:
7
Volltext / DOI:
doi:10.3390/ijms21072460
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32252259
Print-ISSN:
1422-0067
TUM Einrichtung:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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