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Titel:

Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease.

Dokumenttyp:
Article; Journal Article
Autor(en):
Jiang, Yun; Müller, Kristin; Khan, Mahtab A; Assmann, Julian C; Lampe, Josephine; Kilau, Knut; Richter, Marius; Kleint, Maximilian; Ridder, Dirk A; Hübner, Norbert; Schmidt-Supprian, Marc; Wenzel, Jan; Schwaninger, Markus
Abstract:
Cerebral small-vessel diseases (SVDs) often follow a progressive course. Little is known about the function of angiogenesis, which potentially induces regression of SVDs. Here, we investigated angiogenesis in a mouse model of incontinentia pigmenti (IP), a genetic disease comprising features of SVD. IP is caused by inactivating mutations of Nemo, the essential component of NF-κB signaling. When deleting Nemo in the majority of brain endothelial cells (NemobeKO mice), the transcriptional profile...     »
Zeitschriftentitel:
J Cereb Blood Flow Metab
Jahr:
2021
Band / Volume:
41
Heft / Issue:
2
Seitenangaben Beitrag:
219-235
Volltext / DOI:
doi:10.1177/0271678X20910522
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32151223
Print-ISSN:
0271-678X
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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