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Titel:

Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Klapproth, Sarah; Richter, Karsten; Türk, Clara; Bock, Theresa; Bromberger, Thomas; Dominik, Julian; Huck, Kathrin; Pfaller, Kristian; Hess, Michael W; Reichel, Christoph A; Krüger, Marcus; Nakchbandi, Inaam A; Moser, Markus
Abstract:
Osteoclasts form special integrin-mediated adhesion structures called sealing zones that enable them to adhere to and resorb bone. Sealing zones consist of densely packed podosomes tightly interconnected by actin fibers. Their formation requires the presence of the hematopoietic integrin regulator kindlin-3 (also known as Fermt3). In this study, we investigated osteoclasts and their adhesion structures in kindlin-3 hypomorphic mice expressing only 5-10% of the kindlin-3 level of wild-type mice....     »
Zeitschriftentitel:
J Cell Sci
Jahr:
2021
Band / Volume:
134
Heft / Issue:
22
Volltext / DOI:
doi:10.1242/jcs.259040
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34704600
Print-ISSN:
0021-9533
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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