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- Title:
Ventricular volume, white matter alterations and outcome of major depression and their relationship to endocrine parameters - A pilot study.
- Document type:
- Article; Journal Article
- Author(s):
- Murck, Harald; Luerweg, Benjamin; Hahn, Johannes; Braunisch, Matthias; Jezova, Daniela; Zavorotnyy, Maxim; Konrad, Carsten; Jansen, Andreas; Kircher, Tilo
- Abstract:
- OBJECTIVES: Brain morphology and its relation to endocrine parameters were examined, in order to determine the link of these parameters to treatment outcome to psychopharmacological treatment in depressed patients. METHODS: We examined the potentially predictive value of Magnetic Resonance Imaging (MRI) parameters related to mineralocorticoid receptor (MR) function on the treatment outcome of depression. 16 inpatients with a major depressive episode (MDE) were studied at baseline and 14 of them approximately six weeks later. Physiological biomarkers and 3-T-structural MRI based volume measures, using FreeSurfer 6.0 software, were determined. RESULTS: Non-responders (<50% reduction of HAMD-21; n = 6) had a significantly smaller volume of the right anterior cingulate cortex, a significantly larger ventricle to brain ratio (VBR) and third ventricle volume, and smaller volumes of the central and central-anterior corpus callosum (CC) in comparison to responders (n = 7; all p ≤ 0.05). Correlational analysis (Spearman) demonstrated that larger ventricle volume was correlated to a worse treatment outcome, higher body mass index (BMI) and smaller CC segment volume, whereas the total CC volume was negatively correlated to the saliva aldosterone/cortisol concentration ratio (AC-ratio). CONCLUSION: Large ventricular volume may be a predictive marker for worse treatment response to standard antidepressant treatment, potentially via compression of white matter structures. A mediating role of the previously identified markers BMI and the AC-ratio, is suggested.
- Journal title abbreviation:
- World J Biol Psychiatry
- Year:
- 2021
- Journal volume:
- 22
- Journal issue:
- 2
- Pages contribution:
- 104-118
- Fulltext / DOI:
- doi:10.1080/15622975.2020.1757754
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/32306867
- Print-ISSN:
- 1562-2975
- TUM Institution:
- Fachgebiet Nephrologie (Prof. Heemann)
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