Accuracy of iodine quantification in dual-layer spectral CT: Influence of iterative reconstruction, patient habitus and tube parameters.

Sauter, Andreas P; Kopp, Felix K; Münzel, Daniela; Dangelmaier, Julia; Renz, Martin; Renger, Bernhard; Braren, Rickmer; Fingerle, Alexander A; Rummeny, Ernst J; Noël, Peter B

doi:10.1016/j.ejrad.2018.03.009

journal article

Titel:: Accuracy of iodine quantification in dual-layer spectral CT: Influence of iterative reconstruction, patient habitus and tube parameters.
Dokumenttyp:: Journal Article
Autor(en):: Sauter, Andreas P; Kopp, Felix K; Münzel, Daniela; Dangelmaier, Julia; Renz, Martin; Renger, Bernhard; Braren, Rickmer; Fingerle, Alexander A; Rummeny, Ernst J; Noël, Peter B
Abstract:: Evaluation of the influence of iterative reconstruction, tube settings and patient habitus on the accuracy of iodine quantification with dual-layer spectral CT (DL-CT).A CT abdomen phantom with different extension rings and four iodine inserts (1, 2, 5 and 10 mg/ml) was scanned on a DL-CT. The phantom was scanned with tube-voltages of 120 and 140 kVp and CTDI of 2.5, 5, 10 and 20 mGy. Reconstructions were performed for eight levels of iterative reconstruction (i0-i7). Diagnostic dose levels are classified depending on patient-size and radiation dose.Measurements of iodine concentration showed accurate and reliable results. Taking all CTDI-levels into account, the mean absolute percentage difference (MAPD) showed less accuracy for low CTDI-levels (2.5 mGy: 34.72%) than for high CTDI-levels (20 mGy: 5.89%). At diagnostic dose levels, accurate quantification of iodine was possible (MAPD 3.38%). Level of iterative reconstruction did not significantly influence iodine measurements. Iodine quantification worked more accurately at a tube voltage of 140 kVp. Phantom size had a considerable effect only at low-dose-levels; at diagnostic dose levels the effect of phantom size decreased (MAPD <5% for all phantom sizes).With DL-CT, even low iodine concentrations can be accurately quantified. Accuracies are higher when diagnostic radiation doses are employed.
Zeitschriftentitel:: Eur J Radiol
Jahr:: 2018
Band / Volume:: 102
Seitenangaben Beitrag:: 83-88
Volltext / DOI:: doi:10.1016/j.ejrad.2018.03.009
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/29685549
Print-ISSN:: 0720-048X
TUM Einrichtung:: Institut für Diagnostische und Interventionelle Radiologie
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