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Title:

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.

Document type:
Journal Article
Author(s):
Tsuda, Motoyuki; Fukuda, Akihisa; Roy, Nilotpal; Hiramatsu, Yukiko; Leonhardt, Laura; Kakiuchi, Nobuyuki; Hoyer, Kaja; Ogawa, Satoshi; Goto, Norihiro; Ikuta, Kozo; Kimura, Yoshito; Matsumoto, Yoshihide; Takada, Yutaka; Yoshioka, Takuto; Maruno, Takahisa; Yamaga, Yuichi; Kim, Grace E; Akiyama, Haruhiko; Ogawa, Seishi; Wright, Christopher V; Saur, Dieter; Takaori, Kyoichi; Uemoto, Shinji; Hebrok, Matthias; Chiba, Tsutomu; Seno, Hiroshi
Abstract:
Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that BRG1 inhibits the formation of intraductal pancreatic mucinous neoplasm (IPMN) and that IPMN-derived PDA originated from ductal cells. However, the role of BRG1 in pancreatic intraepithelial neoplasia-derived (PanIN-derived) PDA that originated from acinar cells remains elusive. Here, we found that exclusive elimination of Brg1 in acinar c...     »
Journal title abbreviation:
J Clin Invest
Year:
2018
Journal volume:
128
Journal issue:
8
Pages contribution:
3475-3489
Fulltext / DOI:
doi:10.1172/JCI94287
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30010625
Print-ISSN:
0021-9738
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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