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Title:

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fabian, Alexander; Stegner, Simon; Miarka, Lauritz; Zimmermann, Johannes; Lenk, Lennart; Rahn, Sascha; Buttlar, Jann; Viol, Fabrice; Knaack, Hendrike; Esser, Daniela; Schäuble, Sascha; Großmann, Peter; Marinos, Georgios; Häsler, Robert; Mikulits, Wolfgang; Saur, Dieter; Kaleta, Christoph; Schäfer, Heiner; Sebens, Susanne
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed when liver metastases already emerged. We recently demonstrated that hepatic stromal cells determine the dormancy status along with cancer stem cell (CSC) properties of pancreatic ductal epithelial cells (PDECs) during metastasis. This study investigated the influence of the hepatic microenvironment - and its inflammatory status - on metabolic alterations and how these impact cell growth and CSC-characteristics of PDECs. Coculture wit...     »
Journal title abbreviation:
Cancer Lett
Year:
2019
Journal volume:
453
Pages contribution:
95-106
Fulltext / DOI:
doi:10.1016/j.canlet.2019.03.039
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30930235
Print-ISSN:
0304-3835
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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