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Title:

A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Sun, Qi; Lee, Wendy; Mohri, Yasuaki; Takeo, Makoto; Lim, Chae Ho; Xu, Xiaowei; Myung, Peggy; Atit, Radhika P; Taketo, M Mark; Moubarak, Rana S; Schober, Markus; Osman, Iman; Gay, Denise L; Saur, Dieter; Nishimura, Emi K; Ito, Mayumi
Abstract:
Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages. Currently, there is a lack of animal models that resemble human melanoma initiation and progression. Recent studies using a Tyr-CreER driven mouse model have drawn contradictory conclusions about the potential of melanocyte stem cells (McSCs) to form melanoma. Here, we employ a c-Kit-CreER-driven model that specifically targets McSCs to show that oncogenic McSCs are a bona fide source of melanoma that expand in th...     »
Journal title abbreviation:
Nat Commun
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-019-12733-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31685822
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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