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Title:

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Weber, Julia; de la Rosa, Jorge; Grove, Carolyn S; Schick, Markus; Rad, Lena; Baranov, Olga; Strong, Alexander; Pfaus, Anja; Friedrich, Mathias J; Engleitner, Thomas; Lersch, Robert; Öllinger, Rupert; Grau, Michael; Menendez, Irene Gonzalez; Martella, Manuela; Kohlhofer, Ursula; Banerjee, Ruby; Turchaninova, Maria A; Scherger, Anna; Hoffman, Gary J; Hess, Julia; Kuhn, Laura B; Ammon, Tim; Kim, Johnny; Schneider, Günter; Unger, Kristian; Zimber-Strobl, Ursula; Heikenwälder, Mathias; Schmidt-Suppr...     »
Abstract:
B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer genes remains challenging. Here, we describe PiggyBac transposon tools and mouse models for recessive screening and show their application to study clonal B-cell lymphomagenesis. In a genome-wide screen, we discover BCL genes related to diverse molecular processes, including signaling, transcriptional regulation, chromatin regulation, or...     »
Journal title abbreviation:
Nat Commun
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-019-09180-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30926791
Print-ISSN:
2041-1723
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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