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Title:

Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology.

Document type:
Journal Article
Author(s):
Dantes, Zahra; Yen, Hsi-Yu; Pfarr, Nicole; Winter, Christof; Steiger, Katja; Muckenhuber, Alexander; Hennig, Alexander; Lange, Sebastian; Engleitner, Thomas; Öllinger, Rupert; Maresch, Roman; Orben, Felix; Heid, Irina; Kaissis, Georgios A; Shi, Kuangyu; Topping, Geoffrey J; Stögbauer, Fabian; Wirth, Matthias; Peschke, Katja; Papargyriou, Aristeidis; Rezaee-Oghazi, Massoud; Feldmann, Karin; Schäfer, Arlett P G; Ranjan, Raphela; Lubeseder-Martellato, Clara; Stange, Daniel E; Welsch, Thilo; Martign...     »
Abstract:
One of the major challenges in using pancreatic cancer patient-derived organoids (PDOs) in precision oncology is the time from biopsy to functional characterization. This is particularly true for endoscopic ultrasound-guided fine-needle aspiration biopsies, typically resulting in specimens with limited tumor cell yield. Here, we tested conditioned media of individual PDOs for cell-free DNA to detect driver mutations already early on during the expansion process to accelerate the genetic characte...     »
Journal title abbreviation:
JCI Insight
Year:
2020
Journal volume:
5
Journal issue:
15
Fulltext / DOI:
doi:10.1172/jci.insight.137809
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32614802
Print-ISSN:
2379-3708
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Diagnostische und Interventionelle Radiologie; Institut für Klinische Chemie und Pathobiochemie; Klinik und Poliklinik für Chirurgie; Klinik und Poliklinik für Nuklearmedizin; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Lehrstuhl für Tumormetabolismus (Prof. Algül); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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