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Titel:

The uric acid crystal receptor Clec12A potentiates type I interferon responses.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Li, Kai; Neumann, Konstantin; Duhan, Vikas; Namineni, Sukumar; Hansen, Anne Louise; Wartewig, Tim; Kurgyis, Zsuzsanna; Holm, Christian K; Heikenwalder, Mathias; Lang, Karl S; Ruland, Jürgen
Abstract:
The detection of microbes and damaged host cells by the innate immune system is essential for host defense against infection and tissue homeostasis. However, how distinct positive and negative regulatory signals from immune receptors are integrated to tailor specific responses in complex scenarios remains largely undefined. Clec12A is a myeloid cell-expressed inhibitory C-type lectin receptor that can sense cell death under sterile conditions. Clec12A detects uric acid crystals and limits proinf...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2019
Band / Volume:
116
Heft / Issue:
37
Seitenangaben Beitrag:
18544-18549
Volltext / DOI:
doi:10.1073/pnas.1821351116
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31451663
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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