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Title:

TRAIL/NF-κB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell Lines.

Document type:
Article; Journal Article
Author(s):
Geismann, Claudia; Erhart, Wiebke; Grohmann, Frauke; Schreiber, Stefan; Schneider, Günter; Schäfer, Heiner; Arlt, Alexander
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant neoplasms and registers rising death rates in western countries. Due to its late detection in advanced stages, its extremely aggressive nature and the minimal effectiveness of currently available therapies, PDAC is a challenging problem in the clinical field. One characteristic of PDAC is a distinct desmoplasia consisting of fibroblasts, endothelial and immune cells as well as non-cellular components, contributing to the...     »
Journal title abbreviation:
Int J Mol Sci
Year:
2018
Journal volume:
19
Journal issue:
6
Fulltext / DOI:
doi:10.3390/ijms19061661
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29867042
Print-ISSN:
1422-0067
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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