Acne inversa/hidradenitis suppurativa is a chronic inflammatory skin disease characterized by the appearance of subcutaneous inflammatory nodules, abscesses and formation of fistulas, sinus tracts and contracting scars. In the last years scientific interest in its pathophysiology has increasingly gained interest and numerous reports have aimed to identify crucial aspects leading to the ongoing inflammation. In parallel, new systemic therapeutic approaches have been reported targeting the inflammatory component of the disease. The aim of this review is to give an overview of the clinical presentation and the current knowledge on pathophysiology with a focus on the immune system fueling chronic cutaneous inflammation. Moreover, systemic anti-inflammatory therapy and surgical interventions are described and presented in the context of pathophysiological changes.     «

Acne inversa/hidradenitis suppurativa is a chronic inflammatory skin disease characterized by the appearance of subcutaneous inflammatory nodules, abscesses and formation of fistulas, sinus tracts and contracting scars. In the last years scientific interest in its pathophysiology has increasingly gained interest and numerous reports have aimed to identify crucial aspects leading to the ongoing inflammation. In parallel, new systemic therapeutic approaches have been reported targeting the inflamm...     »